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CBL (gene)
''Cbl'' (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.
== Discovery ==
In 1989 a virally encoded portion of the chromosomal mouse ''Cbl'' gene was the first member of the Cbl family to be discovered and was named ''v-Cbl'' to distinguish it from normal mouse ''c-Cbl''. The virus used in the experiment was a retrovirus known as ''Cas-Br-M'', and was found to have excised approximately a third of the original ''c-Cbl'' gene from mice it was injected into. Sequencing revealed that the portion carried by the retrovirus encoded a ''tyrosine kinase binding domain'', and that this was the oncogenic form as retroviruses carrying full-length ''c-Cbl'' did not induce tumour formation. The resultant transformed retrovirus was found to consistently induce a type of pre-B lymphoma, known as ''Casitas B-lineage lymphoma'', in infected mice.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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